There are several relatively recently built biorefineries in Nebraska, where ethanol production has been hailed by some as a way to increase available fuels while providing a mechanism for revitalizing depopulating communities. Ethanol plants offer a readily available alternative market for farmers selling corn, and the manufacturing facilities provide employment opportunities which are sometimes in short supply in rural areas.
There are significant disadvantages as well, however, i.e. concern that the corn is being removed from the food supply (and thus perhaps contributing to inflated food prices), and serious potential problems with groundwater contamination as a result of the increasing use of these biofuels. Additionally, ethanol has been alleged to be a "clean" fuel, but it is still not healthy for our planet in my opinion from the standpoint of global warming. In fact, ethanol as a gasoline additive may actually be prolonging reliance on fossil fuel gasoline as a primary power source for transportation. It should be possible to develop cleaner technology.
I do not know whether investment in biofuels or biorefineries would be profitable over the long run, but recently construction of these plants has been quite popular in this area and several local educational institutions have developed job training programs for workers in this industry.